Safety Drug Safety Update : Xylometazoline / Oxymetazoline; Increased
Risk of Rebound Congestion, Rhinitis
Medicamentosa, and Tachyphylaxis
with Overuse 
Local case Safety Report : Increased
Risk of Rebound Congestion, Rhinitis
Medicamentosa, and Tachyphylaxis
with Overuse 
EPVC NEWs 
EPVC Tips

(196 ) Newsletter-Hundred ninety Six

Safety Notification : Updated Prescribing Controls and Rising Risks
from Isotretinoin Misuse 
Local Case Safety Report: Reported
Posterior Reversible Encephalopathy
Syndrome in Two Pediatric Oncology
Patients Receiving Cyclophosphamide
Containing Chemotherapy 
EPVC NEWs 
EPVC Tips

(195 ) Newsletter-Hundred ninety Five

Label Update : Medicine-induced Pisa syndrome 
Local Case Safety Report: Urinary incontinence Following Administration
of a Drug Containing Isotretinoin 
EPVC NEWs 
EPVC Tips

(194 ) Newsletter-Hundred ninety Four

Label Update : Drug-induced aseptic meningitis 
Local Case Safety Report: A parent
child report of excessive sleep Following maternal administration of Escitalopram 
EPVC NEWs 
EPVC Tips

(193 ) Newsletter-Hundred ninety Three

Label Update: Mesalazine and idiopathic intracranial hypertension 
Local Case Safety Report: Hidden Risk
on the Plate: Food–Drug Interaction
between Warfarin and leafy greens followed by Ischemic Stroke 
EPVC NEWs 
EPVC Tips

(192 ) Newsletter-Hundred ninety Two

التوعية الدوائية  لعام 2025

Prescriber Update: Attention: Safety of
medicines used to treat ADHD inadults 
Local Case Safety Report: A case of non-compliance 
Safety Signal : Seizures in Breastfed
Infants due to Mothers’ use of Dicyclomine-Containing Products 
EPVC NEWs 
VigiTest 
EPVC Tips

(191 ) Newsletter-Hundred ninety one 

Prescriber Guide: Systemic retinoids
and diffuse idiopathic skeletal hyperostosis (DISH)
Local Case Safety Report: Case series
related to Illegally Imported Dietary
Supplements Marketed for Weight Reduction 2-3
Potential Signal: Potential Signal of
Angina Pectoris Associated with Ocrelizumab Administration 4
Safety Signal : A Safety signal of Seizures Associated with the overdose administration of Pipazetate. 5
EPVC NEWs 6.7-8
EPVC Tip

(190 ) Newsletter-Hundred ninety 

Safety Reminder: Systemic fluoroquinolone antibiotics 
Local Case Report 2 Case Reports from
Cairo Regional Center of Premature Rupture of Membranes and Oligohydramnios
Following Administration of a Drug Containing a Combination of Caffeine Anhydrous, Drotaverine Hydrochloride, and
Paracetamol
EPVC News
Vigitest News
EPVC Tip

(189 ) Newsletter-Hundred eighty nine

Prescriber Update : Hyperkaliemia or
?BRASH syndrome
Local Case Report :Case of Pancytopenia /Shock /Drug toxicity / Diarrhea / Vomiting / Abdominal pain
and Drug toxicity induced by incorrect dose administration of Methotrexate 
EPVC News
EPVC Ti

(188 ) Newsletter-Hundred eighty eight

Safety Alert: : Respiratory Syncytial
Virus (RSV) Vaccines – Small Increased Risk of Guillain-Barré Syndrome in Older Adults 
Local Case Report :Combined Oral
Contraceptive induced Mesenteric
vascular occlusion 
EPVC News 
EPVC Tips 

(187 ) Newsletter-Hundred eighty Seven

Safety Notification: Risk of encephalitis
with varicella vaccines 1
Local Case Report :Fournier Gangrene Following Empagliflozin Administration 3-4
EPVC News
EPVC Tips

(186 ) Newsletter-Hundred eighty Six

Safety Notification: Rare but severe
itching after stopping long-term use of
oral allergy medicines containing cetirizine or levocetirizine 
Safety Reminder: Importance of Rabies Vaccination and Associated Adverse Events 
Local Case Report: Paracetamol induced hepatotoxicity 
EPVC News 
EPVC Tips

(185 ) Newsletter-Hundred eighty five

Local case report Colistimethate sodium induced Bartter's syndrome 
EPVC News 
 VigiTest News 
EPVC Tips

(184 ) Newsletter-Hundred eighty four

DHPC: Risk of Medication Errors with Tranexamic Acid injection Resulting in Inadvertent Intrathecal ( spinal) Injection 
Local Case report statin-induced Muscle-Related Adverse Effects
EPVC News

EPVC Tip

(183 ) Newsletter-Hundred eighty three

DHPC : Thiocolchicoside containing
medicines for systemic use: -important
information on restrictions associated
with the risk of genotoxicity 
Local case report Terbutaline Sulfate
may exacerbate preexisting diabetes 
EPVC News 
EPVC Tips

(182 ) Newsletter-Hundred eighty Two

Mar 2025

Reminder Safety Alert : More prominent safety warnings about the neuropsychiatric effects of Montelukast
Local case report A case report of a
possible drug Interaction between
Levothyroxine and Orlistat 
EPVC News 
EPVC Tips

(181 ) Newsletter-Hundred eighty one

Feb 2025

Potential signal of impaired gastric
emptying associated with the administration of Tirzepatide 
Local case report Glyceryl Trinitrate
in hypertensive emergencies: A case of rapid decline in blood pressure after
an inappropriate initial dose 
EPVC News
EPVC Tips 

(180 ) Newsletter-Hundred eighty

Jan 2025

التوعية الدوائية لعام 2024

Safety Notification ! : Drug-induced
tendinopathy

Local case report Interferon alfa and Neuropsychiatric adverse reactions

EPVC News
EPVC Tips

(179 ) Newsletter-Hundred Seventy nine

DEC 2024

Safety Notification Drug-inducedIN THIS ISSUE

Safety Reminder " Iohexol: Non-

ionic monomeric contrast media

adverse events and preventive

measurements”

EPVC News

EPVC Tips

(178 ) Newsletter-Hundred Seventy eight

Nov 2024

Safety Notification ! New recom- tion is the way through which the promendations to minimize the risk of cesses for authorizing, regulatmeningioma with medicines con- ing, monitoring and evaluating the
taining medroxyprogesterone ace- safety of any pharmaceutical product
tate 
or medical device take place, in addi Levofloxacin Incorrect administration to disseminating any safety infortion rate medication error. mation for public health programs,

Case Report: Paclitaxel induced healthcare professionals, and the
hypersensitivity reactions 

Egyptian citizen.
EPVC News 

The Pharmaceutical vigilance ad EPVC Tips

(177 ) Newsletter-Hundred Seventy Seven

Oct 2024

Safety Notification ! Medicines
containing Garcinia gummi-gutta
(Garcinia cambogia) or hydroxycitric acid (HCA) 
Local Case Report: Cytarabine induced CNS adverse reactions 
EPVC News 

EPVC Tips 6

(176 ) Newsletter-Hundred Seventy Six

Sep2024

Safety Notification: Pseudoephedrinecontraindications 
Local case: Management of irinotecan related diarrhea 
EPVC News
EPVC Tips

(175 ) Newsletter-Hundred Seventy five

August2024

Safety Notification: Medicine-induced
hyponatremia: increased risks in older
people 
Safety Notification: Intravenous
Rituximab and Infusion-related
reactions 
EPVC News 
EPVC Tips 

(174) Newsletter-Hundred Seventy Four 

July 2024

Safety Notification: Interacting safely
with low-dose methotrexate 
Safety Notification: Promethazine
(oral): Do not use in children under
 years of age due to the risk of
psychiatric and central nervous system side effects 
EPVC News 
EPVC Tip

(173) Newsletter-Hundred Seventy three 

June 2024

Safety Notification: Unintentional
poisoning of some products 
Local Case Report: Furosemide
exposure during pregnancy 
EPVC News 
EPVC Tips 

(172) Newsletter-Hundred Seventy two 

MAY 2024

Safety Notification Drug-induced
phospholipids 
Safety Notification: Fishbane Reaction
Hypersensitivity Type to Intravenous
Iron Preparations 
Local Case Report: Potassium
    chloride Contraindications 
EPVC News 
EPVC Tips 

(171) Newsletter-Hundred Seventy one 

APR 2024

Safety Notification Uterine bleeding in people taking oral anticoagulant therapy 1
Safety Notification: Glucose meters and test strips: Safe way to use
them 2
Safety Notification ! : Radiation
Recall Phenomenon associated
with chemotherapy and certain
medications 3-4
EPVC News 5
EPVC Tips 6

(170) Newsletter-Hundred Seventy 

MAR 2024

Safety Notification ! Infusion-related
reactions – not all allergy related 1
Safety Notification !Symmetrical drug
-related intertriginous and flexural exanthema (SDRIFE) 2-3
Local case report " " Four Cases of
Keratitis and Corneal Melt Associated
with Local Anesthetic Eye Drops Use
4-5-6
EPVC News 7
EPVC Tips

(169) Newsletter-Hundred Sixty nine

Feb 2024

Safety Notification ! Infusion-related
reactions – not all allergy related 1-2
Local case report " Adverse events
following administration of Phyto
menadione (Vitamin K) intravenous
infusion.” 3-4
EPVC News 5
EPVC Tips 6

(168) Newsletter-Hundred Sixty eight

Jan 2024

التوعية الدوائية لعام 2023

Safety Notification ! : Antidepressant
withdrawal: taper antidepressants
slowly 1
Local case report Cytarabine may induce tumor lysis syndrome in acute
myeloid leukemia cases.” 2-3
Potential signal of Necrotizing soft
tissue infections with vincristine 4
Potential signal (2) Adverse outcomes
of uncompleted pregnancy following
insulin exposure 5
EPVC News 6
EPVC Tips 7

(167) Newsletter-Hundred Sixty seven

December 2023

Safety Alert ! : Vanishing bile duct
syndrome – a complication of drug
induced liver injury 1
Case report from Cairo: " Iohexol:
Non-ionic monomeric contrast media adverse events and preventive
measurements” 2-3-4-5
EPVC News 6
EPVC Tips 7

(166) Newsletter-Hundred Sixty six November 2023

Safety Alert ! : Fluoroquinolone antibiotics: suicidal thoughts and behavior 1
Case report from Cairo: Four cases
of serious extrapyramidal side effects after wrong drug dispensing
and dose administration of Cyclizine intravenous injection 2-3
EPVC News 4
EPVC Tips 5

(165) Newsletter-Hundred Sixty five October 2023

Local Alert: Sub-standardized and
Falsified (SF) Product 1
Safety Alert ! : Risk of meningioma
and progestins: General Recommendations to limit this risk 2
Two case reports from Alexandria:
Concerning Intravenous infusion
administration of Ampicillin Sodium and Sulbactam Sodium for two
Neonates resulted in Serious adverse event to Neonates . 3-4-5-6
EPVC News 7
EPVC Tips 8

(164) Newsletter-Hundred Sixty four September 2023

Local Alert: Sub-standardized and
Falsified (SF) Product
Identified Threat: Falsified Versions
Of Glucagon-Like Peptide 1 Receptor Agonist (Glp-1-Ra) Products
2-3
"Fever, Vomiting, Difficulty breathing,
Tachycardia and Cyanosis associated
with Immunoglobulin human normal.
4-5-6
EPVC News 7-8
EPVC Tips 9

(163) Newsletter-Hundred Sixty three August 2023 

Direct-acting oral anticoagulants
(DOACs): Pediatric formulations;
reminder of dose adjustments in patients with renal impairment 1

"Ca acetate caused muscle cramps to a fifth degree kidney failure patient compared to Ca carbonate being used as a phosphate binder " 2-3-4

EPVC News 5

EPVC Tips 6

(162) Newsletter-Hundred Sixty two July 2023 

Emerging Safety Issue: Statin potential risks of myasthenia gravis and ocular myasthenia
Case Study: A female got ischemic stroke while taking the combined hormonal contraceptive pill

EPVC News

EPVC Tips

(161) Newsletter-Hundred Sixty one June 2023

Safety Alert : Buproprion: unmasking of Brugada syndrome

Aflibercept induced endophthalmitis
and vitreous detachment

Two cases from Cairo : Atracurium
besilate- Isoflurane caused cardiac
arrest and bronchospasm due to inappropriate dose adjustment
(Medication error)

EPVC News

EPVC Tips 

(160) Newsletter-Hundred Sixty

May 2023

Consumer Update : Clopidogrel has
been shown to increase rosuvastatin
exposure in patients 
EPVC Investigation reports : Fingolimod induced bradycardia

EPVC Investigation reports (2): Pipazetate
hydrochloride accidental overdose

Two case reports from Alexandria: two
cases of intentional Dexamethasone misuse resulting in Type 2 diabetes mellitus/
Polycystic ovary/Moon face/ Buffalo
hump

EPVC News

EPVC Tips 

(159) Newsletter-Hundred Fifty nine April 2023

Alert: Darzalex , Napizole Counterfeit

DHPC: Levothyroxine containing
products: Biotin interference with

laboratory tests

Case report from Cairo: Isotretinoin causing depression, skin dryness

EPVC News

EPVC Tips 

(158) Newsletter-Hundred fifty eight

March 2023

Alert: Voltaren & Linezolid Counterfeit

DHPC: Hydroxyethyl Starch Solution for Infusion– Reminder of

Safety Measures to Minimize Risk
of Kidney Injury and Death

Local Case Report: Insulin - lack
of Drug Effect

EPVC News EPVC Tips 

(157) Newsletter-Hundred fifty Seven

February 2023

Alert: Averzolid, Restylane & Fortum Counterfeit 
Withdrawal & Suspension: Gemifloxacin 
DHPC: Ceftriaxone & Cefotaxime
– Reminder of Precautions to Minimize Severe Hypersensitivity Reactions and Life-threatening Adverse Events 
Local Case Report: Fexofenadine
- Ghost pill syndrome 
EPVC News 
EPVC Tips 

(156) Newsletter-Hundred fifty six

January 2023

التوعية الدوائية 2022-2021

Alert: Omnevore & Pedicort
Forte Counterfeit 
DHPC: Tixagevimab + Cilgavimab  Updated Dosage Recommendations for Pre-exposure
Prophylaxis 
Local Case Report: Gadoteric
Acid - Two Cases of Cardiac
Arrest 
EPVC News 
EPVC Tips 

(155) Newsletter-Hundred fifty five

December 2022

Alert: Nexium & Vigamox
Counterfeit 

DHPC: Propofol– Reminder of
Instructions for Safe Use 

Local Case Report: Hypersensitivity Reactions 

EPVC News 
EPVC Tips 

(154) Newsletter-Hundred fifty four

November 2022

Alert: Nevanac & Dyspot Counterfiet     

DHPC: Dexmedetomidine -Increased Risk of Mortality in Intensive Care Unit            
Local Case Report: EstradiolValerate + Prasterone Enantate Medication Error                   

(153)Newsletter-Hundred fifty three October 2022

Counterfeit and Commercial Fraud 1 (DHPC):

Colchicine Serious Poisoning – Reminder of the Rules of Proper Use 

 Local Case Report: Tigecycline - Medication Error 

Medical Device: Dermal Filler Do's and Don'ts 

(152) Newsletter-Hundred Fifty two septamber 2022

  Infliximab- Use of Live Vaccines in Infants Exposed in Utero or During Breastfeeding  

  Local Case Report: Cefotaxime - Anaphylactic shock, Hypersensitivity, Hypoxia and Rash

(151) Newsletter-Hundred Fifty One August 2022

  •Citalopram & Escitalopram - Risk of Dosedependent Qt interval prolongation 1

  •Local Case Report: Isotretinoin - Case of Skin rash, dryness and Blurred vision 2

(150) Newsletter-hundred fifty-July 2022

  • Injectable Trime-butine- Risk of Cardiac Tox-icity in the Event of Misuse

    •Local Case Report: Pheno-barbital - Case of Apnea

(149) Newsletter-Hundred Forty Nine June 2022

    • Alert: Xoraxone Vial Counterfeit 1

    • Bone marrow suppression with methotrexate and   trimethoprim or trimethoprim with   sulfamethoxazole 2

    • Local Case Report: Ceftriaxone with ketorolac -   Anaphylactic shock 3

(148) Newsletter-Hundred forty-eight May 2022

• Alert: Unictam Vial Counterfeit
• Reminder of General Measures to Prevent the Nephrotoxicity Risk with High dose Methotrexate
• Local Case Report: Paclitaxel - Convulsions and Coma
• EPVC News

(147) Newsletter-Hundred Forty Seven April 2022

• DHPC:Dapagliflozin 5mg Should No Longer be Used for the Treatment of Type 1 Diabetes Mellitus
• Local Case Report: Alendronic Acid - Case of Osteonecrosis of the Jaw
• EPVC News

(146) Newsletter-Hundred Forty Six March 2022

• DHPC: Donepezil-QTc interval extension and Torsade de Pointes
• Local Case Report: Tranexamic acid - Case of Convulsions
• EPVC News

(145) Newsletter-Hundred Forty five February 2022

• Pholcodine Containing Antitussive Drugs and Risk of Allergic Reaction to Neuromuscular Blocking Agents
• DHPC: Glatiramer acetate Rare Cases of Severe Liver Damage
• Local Case Report: A case of Guillain-Barre syndrome following Janssen COVID-19 vaccine
• EPVC News

(144) Newsletter-Hundred Forty four January 2022

• DHPC: Amiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion Potential for crystallization
• Local Case Report: Case of Drug Dependence and Overdose Following Xylometazoline Nasal Drops Prolonged Administration
• EPVC News

(143) Newsletter-Hundred Forty three Deecember 2021

• DHPC: COVID-19  mRNA  Vaccine Comirnaty: Risk of Myocarditis and Pericarditis.
• Local Case  Report:  A  Case  of Drug Abuse Resulted in Acute Renal  Injury,  Cardiomegaly, Muscle Weakness,  Ulcers,  Sepsis  and  Finally  Death  Following  Paraffin Oil, Anabolic Steroids and Synthol Local Administration

(142) Newsletter-Hundred Forty two November 2021

• COVID-19 Vaccine Astra-Zeneca: Warning for Guillain-Barre syndrome
• Topical corticosteroids: Information on the risk of topical steroid withdrawal reactions
• EPVC News

• Colchicine: High risk of fatality with Colchicine over-dose
• Fingolimod: Updated advice about the risks of serious liver injury and herpes meningoencephalitis
• EPVC News

• Bendamustine: Risk of nonmelanoma skin cancer
• Levodopa DHPC 2
• Local Case Report: Lamivudine and Sulipride

• Obeticholic acid: Restriction of use
• Local Case Report: Fluorouracil
• EPVC News

(138) Newsletter-Hundred Thirty-eight
July 2021

• Polyethylene glycol (PEG) laxatives and starch-based thickeners: risk of aspiration
• Local Case Report: Interaction between Warfarin and Naproxen
• EPVC News

(137) Newsletter-Hundred Thirty-seven
June 2021

• Bupropion: risk of serotonin syndrome
• Local Case Report: Warfarin

(136) Newsletter-Hundred Thirty-six
May 2021

• Erythromycin: Update on Risk of Infantile Hypertrophic Pyloric Stenosis
• Local Case Report: Ceftriaxone
• EPVC News

(135) Newsletter-Hundred Thirty-five
April 2021

• Erythromycin Cardiac Risk and Interaction with Rivaroxaban
• Local Case Report: Furosemide
• EPVC News

(134) Newsletter-Hundred Thirty-four
March 2021

• SSRI/SNRI risk of post-partum hemorrhage
• Local Case Report: Sildenafil
• EPVC News

(133) Newsletter-Hundred Thirty-three
February 2021

• DHPC for Dimethyl Fumarate
• Safety Communication for Emicizumab
• Local Case Report: Cyclizine
• EPVC News

(132) Newsletter-Hundred Thirty-two
January 2021